Ontology highlight
ABSTRACT:
SUBMITTER: Tobola F
PROVIDER: S-EPMC6102642 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
ACS chemical biology 20180612 8
Protein-carbohydrate interactions play crucial roles in biology. Understanding and modifying these interactions is of major interest for fighting many diseases. We took a synthetic biology approach and incorporated noncanonical amino acids into a bacterial lectin to modulate its interactions with carbohydrates. We focused on tryptophan, which is prevalent in carbohydrate binding sites. The exchange of the tryptophan residues with analogs fluorinated at different positions resulted in three disti ...[more]