Ontology highlight
ABSTRACT:
SUBMITTER: Mondal S
PROVIDER: S-EPMC7782748 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Mondal Santanu S Wang Shu S Zheng Yunan Y Sen Sudeshna S Chatterjee Abhishek A Thompson Paul R PR
Nature communications 20210104 1
Citrullination is a post-translational modification (PTM) of arginine that is crucial for several physiological processes, including gene regulation and neutrophil extracellular trap formation. Despite recent advances, studies of protein citrullination remain challenging due to the difficulty of accessing proteins homogeneously citrullinated at a specific site. Herein, we report a technology that enables the site-specific incorporation of citrulline (Cit) into proteins in mammalian cells. This a ...[more]