Ontology highlight
ABSTRACT:
SUBMITTER: Kwan EE
PROVIDER: S-EPMC6105541 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Kwan Eugene E EE Zeng Yuwen Y Besser Harrison A HA Jacobsen Eric N EN
Nature chemistry 20180716 9
Nucleophilic aromatic substitution (S<sub>N</sub>Ar) is one of the most widely applied reaction classes in pharmaceutical and chemical research, providing a broadly useful platform for the modification of aromatic ring scaffolds. The generally accepted mechanism for S<sub>N</sub>Ar reactions involves a two-step addition-elimination sequence via a discrete, non-aromatic Meisenheimer complex. Here we use <sup>12</sup>C/<sup>13</sup>C kinetic isotope effect (KIE) studies and computational analyses ...[more]