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Molecular Analysis of a blaIMP-1-Harboring Class 3 Integron in Multidrug-Resistant Pseudomonas fulva.


ABSTRACT: A multidrug-resistant (MDR) Pseudomonas fulva strain was isolated in 2006 from a urine sample. The isolate harbored the blaIMP-1 gene, which was located in a chromosomal Tn402-like class 3 integron as a gene cassette array of aacA31-fosE-blaIMP-1 Two mutations in gyrA and one mutation in parC were detected in quinolone-resistance-determining regions (QRDRs). We report a full-length, novel, blaIMP-1-carrying class 3 integron. This integron, together with mutations in QRDRs, could have influenced the MDR phenotype.

SUBMITTER: Yamamoto M 

PROVIDER: S-EPMC6105817 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Molecular Analysis of a <i>bla</i><sub>IMP-1</sub>-Harboring Class 3 Integron in Multidrug-Resistant Pseudomonas fulva.

Yamamoto Masaki M   Matsumura Yasufumi Y   Gomi Ryota R   Matsuda Tomonari T   Nakano Satoshi S   Nagao Miki M   Tanaka Michio M   Ichiyama Satoshi S  

Antimicrobial agents and chemotherapy 20180727 8


A multidrug-resistant (MDR) <i>Pseudomonas fulva</i> strain was isolated in 2006 from a urine sample. The isolate harbored the <i>bla</i><sub>IMP-1</sub> gene, which was located in a chromosomal Tn<i>402</i>-like class 3 integron as a gene cassette array of <i>aacA31-fosE-bla</i><sub>IMP-1</sub> Two mutations in <i>gyrA</i> and one mutation in <i>parC</i> were detected in quinolone-resistance-determining regions (QRDRs). We report a full-length, novel, <i>bla</i><sub>IMP-1</sub>-carrying class 3  ...[more]

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