Ontology highlight
ABSTRACT:
SUBMITTER: Dabos L
PROVIDER: S-EPMC6105830 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Dabos Laura L Bogaerts Pierre P Bonnin Remy A RA Zavala Agustin A Sacré Pierre P Iorga Bogdan I BI Huang Daniel T DT Glupczynski Youri Y Naas Thierry T
Antimicrobial agents and chemotherapy 20180727 8
A multidrug-resistant <i>Klebsiella pneumoniae</i> 1210 isolate with reduced carbapenem susceptibility revealed the presence of a novel plasmid-encoded <i>bla</i><sub>OXA-48-like</sub> gene, named <i>bla</i><sub>OXA-519</sub> The 60.7-kb plasmid (pOXA-519) was similar to the IncL-OXA-48 prototypical plasmid except for a ca. 2-kb deletion due to an IS<i>1R</i> insertion. OXA-519 differed from OXA-48 by a Val120Leu substitution, which resulted in an overall reduced β-lactam-hydrolysis profile, exc ...[more]