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Genetic and Biochemical Characterization of OXA-535, a Distantly Related OXA-48-Like ?-Lactamase.


ABSTRACT: OXA-535 is a chromosome-encoded carbapenemase of Shewanella bicestrii JAB-1 that shares only 91.3% amino acid sequence identity with OXA-48. Catalytic efficiencies are similar to those of OXA-48 for most ?-lactams, except for ertapenem, where a 2,000-fold-higher efficiency was observed with OXA-535. OXA-535 and OXA-436, a plasmid-encoded variant of OXA-535 differing by three amino acids, form a novel cluster of distantly related OXA-48-like carbapenemases. Comparison of blaOXA-535 and blaOXA-436 genetic environments suggests that an ISCR1 may be responsible for blaOXA-436 gene mobilization from the chromosome of Shewanella spp. to plasmids.

SUBMITTER: Dabos L 

PROVIDER: S-EPMC6153822 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Genetic and Biochemical Characterization of OXA-535, a Distantly Related OXA-48-Like β-Lactamase.

Dabos L L   Jousset A B AB   Bonnin R A RA   Fortineau N N   Zavala A A   Retailleau P P   Iorga B I BI   Naas T T  

Antimicrobial agents and chemotherapy 20180924 10


OXA-535 is a chromosome-encoded carbapenemase of <i>Shewanella bicestrii</i> JAB-1 that shares only 91.3% amino acid sequence identity with OXA-48. Catalytic efficiencies are similar to those of OXA-48 for most β-lactams, except for ertapenem, where a 2,000-fold-higher efficiency was observed with OXA-535. OXA-535 and OXA-436, a plasmid-encoded variant of OXA-535 differing by three amino acids, form a novel cluster of distantly related OXA-48-like carbapenemases. Comparison of <i>bla</i><sub>OXA  ...[more]

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