Ontology highlight
ABSTRACT:
SUBMITTER: Ilinykh PA
PROVIDER: S-EPMC6107261 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Ilinykh Philipp A PA Santos Rodrigo I RI Gunn Bronwyn M BM Kuzmina Natalia A NA Shen Xiaoli X Huang Kai K Gilchuk Pavlo P Flyak Andrew I AI Younan Patrick P Alter Galit G Crowe James E JE Bukreyev Alexander A
PLoS pathogens 20180823 8
Recent studies suggest that some monoclonal antibodies (mAbs) specific for ebolavirus glycoprotein (GP) can protect experimental animals against infections. Most mAbs isolated from ebolavirus survivors appeared to target the glycan cap or the stalk region of the viral GP, which is the envelope protein and the only antigen inducing virus-neutralizing antibody response. Some of the mAbs were demonstrated to be protective in vivo. Here, a panel of mAbs from four individual survivors of ebolavirus i ...[more]