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Chiral ¹H NMR of Atropisomeric Quinazolinones With Enantiopure Phosphoric Acids.

ABSTRACT: A chiral phosphoric acid promoted enantioselective NMR analysis of atropisomeric quinazolinones was described, in which a variety of racemic arylquinazolinones such as afloqualone and IC-87114 were well recognized with up to 0. 21 ppm ??? value. With this method, the optical purities of different non-racemic substrates can be fast evaluated with high accuracy.

SUBMITTER: Wu C

PROVIDER: S-EPMC6107746 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Chiral 1H NMR of Atropisomeric Quinazolinones With Enantiopure Phosphoric Acids.

Wu Chaofei C Liu Hongxin H Li Juan J Xiao Hong-Ping HP Li Xinhua X Jiang Jun J

Frontiers in chemistry 20180817

A chiral phosphoric acid promoted enantioselective NMR analysis of atropisomeric quinazolinones was described, in which a variety of racemic arylquinazolinones such as afloqualone and IC-87114 were well recognized with up to 0. 21 ppm ΔΔδ value. With this method, the optical purities of different non-racemic substrates can be fast evaluated with high accuracy. ...[more]

PMID: 30175093

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