Ontology highlight
ABSTRACT:
SUBMITTER: Pai AA
PROVIDER: S-EPMC6110457 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Pai Athma A AA Paggi Joseph M JM Yan Paul P Adelman Karen K Burge Christopher B CB
PLoS genetics 20180827 8
Recursive splicing, a process by which a single intron is removed from pre-mRNA transcripts in multiple distinct segments, has been observed in a small subset of Drosophila melanogaster introns. However, detection of recursive splicing requires observation of splicing intermediates that are inherently unstable, making it difficult to study. Here we developed new computational approaches to identify recursively spliced introns and applied them, in combination with existing methods, to nascent RNA ...[more]