Ontology highlight
ABSTRACT:
SUBMITTER: Nishi R
PROVIDER: S-EPMC6297141 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Nishi Ryotaro R Wijnhoven Paul W G PWG Kimura Yusuke Y Matsui Misaki M Konietzny Rebecca R Wu Qian Q Nakamura Keisuke K Blundell Tom L TL Kessler Benedikt M BM
Scientific reports 20181217 1
Non-homologous end-joining (NHEJ), which can promote genomic instability when dysfunctional, is a major DNA double-strand break (DSB) repair pathway. Although ubiquitylation of the core NHEJ factor, Ku (Ku70-Ku80), which senses broken DNA ends, is important for its removal from sites of damage upon completion of NHEJ, the mechanism regulating Ku ubiquitylation remains elusive. We provide evidence showing that the ubiquitin carboxyl-terminal hydrolase L3 (UCHL3) interacts with and directly deubiq ...[more]