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FADS1-FADS2 genetic polymorphisms are associated with fatty acid metabolism through changes in DNA methylation and gene expression.

ABSTRACT: BACKGROUND:Genome-wide association studies (GWASs) have shown that genetic variants are important determinants of free fatty acid levels. The mechanisms underlying the associations between genetic variants and free fatty acid levels are incompletely understood. Here, we aimed to identify genetic markers that could influence diverse fatty acid levels in a Chinese population and uncover the molecular mechanisms in terms of DNA methylation and gene expression. RESULTS:We identified strong associations between single-nucleotide polymorphisms (SNPs) in the fatty acid desaturase (FADS) region and multiple polyunsaturated fatty acids. Expression quantitative trait locus (eQTL) analysis of rs174570 on FADS1 and FADS2 mRNA levels proved that minor allele of rs174570 was associated with decreased FADS1 and FADS2 expression levels (P?

SUBMITTER: He Z

PROVIDER: S-EPMC6114248 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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FADS1-FADS2 genetic polymorphisms are associated with fatty acid metabolism through changes in DNA methylation and gene expression.

He Zhen Z Zhang Rong R Jiang Feng F Zhang Hong H Zhao Aihua A Xu Bo B Jin Li L Wang Tao T Jia Wei W Jia Weiping W Hu Cheng C

Clinical epigenetics 20180829 1

<h4>Background</h4>Genome-wide association studies (GWASs) have shown that genetic variants are important determinants of free fatty acid levels. The mechanisms underlying the associations between genetic variants and free fatty acid levels are incompletely understood. Here, we aimed to identify genetic markers that could influence diverse fatty acid levels in a Chinese population and uncover the molecular mechanisms in terms of DNA methylation and gene expression.<h4>Results</h4>We identified s ...[more]

PMID: 30157936

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