Ontology highlight
ABSTRACT:
SUBMITTER: Chong CM
PROVIDER: S-EPMC6115391 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Chong Cheong-Meng CM Ke Minjing M Tan Yuan Y Huang Zhijian Z Zhang Ke K Ai Nana N Ge Wei W Qin Dajiang D Lu Jia-Hong JH Su Huanxing H
Cell death & disease 20180829 9
Autophagy impairment is commonly implicated in the pathological characteristic of Alzheimer's disease (AD). Presenilin 1 (PS1) expression in human brain gradually decreases with age and its mutations account for the most common cases of early-onset familial Alzheimer's disease (FAD). The dominant autophagy phenotypes occur in PS1-knockout and PS1 mutant neurons; it is still unknown whether PS1 deficiency causes serious autophagy impairment in neural stem cells (NSCs). Herein, we generated the he ...[more]