Ontology highlight
ABSTRACT:
SUBMITTER: Leitch JA
PROVIDER: S-EPMC6115624 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Leitch Jamie A JA Fuentes de Arriba Angel L AL Tan Joanne J Hoff Oskar O Martínez Carlos M CM Dixon Darren J DJ
Chemical science 20180706 32
A visible light mediated iridium photocatalysed reverse polarity Povarov reaction of aryl imines and electron deficient alkenes is described. Operating <i>via</i> a putative nucleophilic α-amino radical, generated by a proton coupled electron transfer process, addition to a range of conjugated electron deficient alkene substrates affords substituted tetrahydroquinoline products in high yields and with typically good to excellent diastereoselectivity in favor of the <i>trans</i> diastereoisomer. ...[more]