Ontology highlight
ABSTRACT:
SUBMITTER: Huang Z
PROVIDER: S-EPMC6117455 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Huang Zhiyao Z Barker Diana D Gibbins Jonathan M JM Dash Philip R PR
Experimental cell research 20180709 2
Focal adhesions (FAs) play an important role in cancer cell migration and metastasis by linking the actin cytoskeleton to the extracellular matrix, allowing the cell to generate traction. SUMOylation is a post-translational modification of proteins on lysine residues that can affect protein localisation, turnover and protein-protein interactions. In this study, we demonstrate that talin, a key component of FAs, can be post-translationally modified by SUMOylation in MDA-MB-231 breast cancer cells ...[more]