Quantum Dot-Based Probes for Labeling and Imaging of Cells that Express Matrix Metalloproteinases.
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ABSTRACT:
SUBMITTER: Benito-Alifonso D
PROVIDER: S-EPMC6120729 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Publications
Quantum Dot-Based Probes for Labeling and Imaging of Cells that Express Matrix Metalloproteinases.
Benito-Alifonso David D Richichi Barbara B Baldoneschi Veronica V Berry Monica M Fragai Marco M Salerno Gianluca G Galan M Carmen MC Nativi Cristina C
ACS omega 20180823 8
The practical synthesis of novel multivalent fluorescent quantum-dot-based probes to target cellular matrix metalloproteinases (MMPs) (MT-MMPs) is reported. We show that these probes, which are decorated with a nanomolar water-soluble MMP inhibitor, can be used to label preferentially the surface of cancer cells that are known to express MMPs while no binding was observed on cells that do not. ...[more]
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