Declining Lung Function and Cardiovascular Risk: The ARIC Study.

ABSTRACT:

Background

Pulmonary dysfunction predicts incident cardiovascular disease (CVD).

Objectives

The purpose of this study was to evaluate whether longitudinal decline in lung function is associated with incident heart failure (HF), coronary heart disease (CHD), and stroke.

Methods

Among 10,351 participants in the ARIC (Atherosclerosis Risk In Communities) study free of CVD, rapid lung function decline was defined as the greatest quartile (n = 2,585) of decline in either forced expiratory volume in 1 s (FEV₁) (>1.9% decline/year) or forced vital capacity (FVC) (>2.1% decline/year) over 2.9 ± 0.2 years. The relationship between rapid decline in FEV₁ or FVC and subsequent incident HF, CHD, stroke, or a composite of these was assessed using multivariable

SUBMITTER: Silvestre OM 

PROVIDER: S-EPMC6121739 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature