Dataset Information

Association of lung function with cardiovascular risk: a cohort study.

ABSTRACT:

Background

The potential effects of pulmonary dysfunction on cardiovascular diseases (CVD) are receiving attention. We aimed to investigate and quantify the cross-sectional and longitudinal associations between lung function and overall cardiovascular risk among Chinese general population.

Methods

We studied 4019 participants from the Wuhan-Zhuhai cohort, with a follow-up of 3 years. A multivariable risk algorithm generated from the Framingham study was used to calculate individuals' overall cardiovascular risk i.e. 10-Year CVD Risk, which was further classified into 2 categories: low (ResultsCross-sectionally, each 5% decrease in FEV₁/FVC was associated with a 0.47% increase in 10-Year CVD Risk (P?1/FVC. The OR (95% CI) for high CVD risk in the lowest group of FEV₁/FVC (1/FVC. Compared with the highest group of FEV₁/FVC, the RR (95% CI) for high CVD risk in the lowest group (COPD) was 4.06 (1.46, 11.26). Analyses of 10-Year CVD Risk with FVC or FEV₁ showed similar trends and significant associations (all P?ConclusionReduced lung function was cross-sectionally and longitudinally associated with increased cardiovascular risk in Chinese general population.

SUBMITTER: Wang B

PROVIDER: S-EPMC6219159 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Publications

Association of lung function with cardiovascular risk: a cohort study.

Wang Bin B Zhou Yun Y Xiao Lili L Guo Yanjun Y Ma Jixuan J Zhou Min M Shi Tingming T Tan Aijun A Yuan Jing J Chen Weihong W

Respiratory research 20181106 1

<h4>Background</h4>The potential effects of pulmonary dysfunction on cardiovascular diseases (CVD) are receiving attention. We aimed to investigate and quantify the cross-sectional and longitudinal associations between lung function and overall cardiovascular risk among Chinese general population.<h4>Methods</h4>We studied 4019 participants from the Wuhan-Zhuhai cohort, with a follow-up of 3 years. A multivariable risk algorithm generated from the Framingham study was used to calculate individua ...[more]

PMID: 30400894

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Project description:ObjectivesVasodilation of the peripheral arteries during reactive hyperaemia depends in part on release of nitric oxide from endothelial cells. Previous studies mainly employed a fingertip tonometric device to derive pulse wave amplitude (PWA) and PWA hyperaemic changes. An alternative approach is based on photoplethysmography (PPG). We sought to evaluate the correlates of digital PPG PWA hyperaemic responses as a measure of peripheral vascular function.DesignThe Flemish Study on Environment, Genes and Health Outcomes (FLEMENGHO) is a population-based cohort study.SettingRespondents were examined at one centre in northern Belgium.ParticipantsFor this analysis, our sample consisted of 311 former participants (53.5% women; mean age 52.6 years; 43.1% hypertensive), who were examined from January 2010 until March 2012 (response rate 85.1%).Primary outcome measuresUsing a fingertip PPG device, we measured digital PWA at baseline and at 30 s intervals for 4 min during reactive hyperaemia induced by a 5 min forearm cuff occlusion. We performed stepwise regression to identify correlates of the hyperaemic response ratio for each 30 s interval after cuff deflation.ResultsThe maximal hyperaemic response was detected in the 30-60 s interval. The explained variance for the PPG PWA ratio ranged from 9.7% at 0-30 s interval to 22.5% at 60-90 s time interval. The hyperaemic response at each 30 s interval was significantly higher in women compared with men (p?0.001). The PPG PWA changes at 0-90 s intervals decreased with current smoking (p?0.0007) and at 0-240 s intervals decreased with higher body mass index (p?0.035). These associations with sex, current smoking and body mass index were mutually independent.ConclusionsOur study is the first to implement the new PPG technique to measure digital PWA hyperaemic changes in a general population. Hyperaemic response, as measured by PPG, is inversely associated with traditional cardiovascular risk factors such as male sex, smoking and obesity.

Dataset Information

Association of lung function with cardiovascular risk: a cohort study.

Background

Methods

Publications

Association of lung function with cardiovascular risk: a cohort study.

Similar Datasets

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