Ontology highlight
ABSTRACT:
SUBMITTER: Mann KM
PROVIDER: S-EPMC6124494 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Mann Karen M KM Newberg Justin Y JY Black Michael A MA Jones Devin J DJ Amaya-Manzanares Felipe F Guzman-Rojas Liliana L Kodama Takahiro T Ward Jerrold M JM Rust Alistair G AG van der Weyden Louise L Yew Christopher Chin Kuan CC Waters Jill L JL Leung Marco L ML Rogers Keith K Rogers Susan M SM McNoe Leslie A LA Selvanesan Luxmanan L Navin Nicholas N Jenkins Nancy A NA Copeland Neal G NG Mann Michael B MB
Nature biotechnology 20160801 9
A central challenge in oncology is how to kill tumors containing heterogeneous cell populations defined by different combinations of mutated genes. Identifying these mutated genes and understanding how they cooperate requires single-cell analysis, but current single-cell analytic methods, such as PCR-based strategies or whole-exome sequencing, are biased, lack sequencing depth or are cost prohibitive. Transposon-based mutagenesis allows the identification of early cancer drivers, but current seq ...[more]