Ontology highlight
ABSTRACT:
SUBMITTER: Kojo S
PROVIDER: S-EPMC6125603 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Kojo Satoshi S Yasmin Nighat N Muroi Sawako S Tenno Mari M Taniuchi Ichiro I
Nature communications 20180905 1
An intronic silencer, S4, in the Cd4 gene has been shown to be responsible for the helper-lineage-specific expression of CD4; S4 requires Runx complex binding to exert its silencer function against the enhancer-mediated Cd4 activation by modulating the epigenetic state of the Cd4 gene. Here we identify a late-acting maturation enhancer. Bcl11b plays essential roles for activation of both the early-acting proximal enhancer and maturation enhancer of Cd4. Notably, Runx complexes suppress these enh ...[more]