Dataset Information

Involvement of the Cingulate Cortex in Anosognosia: A Multimodal Neuroimaging Study in Alzheimer's Disease Patients.

ABSTRACT:

Background

Anosognosia is a frequent symptom of Alzheimer's disease (AD), but its neural substrates remain in question.

Objective

In this study, we combined neuroimaging with a neuropsychological evaluation to assess neural substrates of anosognosia.

Methods

We prospectively recruited 30 patients with probable early-stage AD and matched healthy controls. Participants underwent MRI, FDG-PET, and a neuropsychological evaluation that includes an assessment of anosognosia. In the AD group, correlations between the anosognosia score, neuroimaging modalities, and neuropsychological performance were performed.

Results

Atrophy and hypometabolism were correlated with the anosognosia score in the left dorsal anterior cingulate cortex. The anosognosia score was also correlated with atrophy of the cerebellar vermis, the left postcentral gyrus, and the right fusiform gyrus. No relation was found between anosognosia and the neuropsychological assessment.

Discussion

Structural and metabolic alteration in the dorsal anterior cingulate cortex seems to be associated with a diminution of awareness in patients with early-stage AD.

SUBMITTER: Guerrier L

PROVIDER: S-EPMC6130407 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Involvement of the Cingulate Cortex in Anosognosia: A Multimodal Neuroimaging Study in Alzheimer's Disease Patients.

Guerrier Laura L Le Men Johanne J Gane Anaıs A Planton Mélanie M Salabert Anne-Sophie AS Payoux Pierre P Dumas Hervé H Bonneville Fabrice F Péran Patrice P Pariente Jérémie J

Journal of Alzheimer's disease : JAD 20180101 2

<h4>Background</h4>Anosognosia is a frequent symptom of Alzheimer's disease (AD), but its neural substrates remain in question.<h4>Objective</h4>In this study, we combined neuroimaging with a neuropsychological evaluation to assess neural substrates of anosognosia.<h4>Methods</h4>We prospectively recruited 30 patients with probable early-stage AD and matched healthy controls. Participants underwent MRI, FDG-PET, and a neuropsychological evaluation that includes an assessment of anosognosia. In t ...[more]

PMID: 30056422

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Dataset Information

Involvement of the Cingulate Cortex in Anosognosia: A Multimodal Neuroimaging Study in Alzheimer's Disease Patients.

Background

Objective

Methods

Results

Discussion

Publications

Involvement of the Cingulate Cortex in Anosognosia: A Multimodal Neuroimaging Study in Alzheimer's Disease Patients.

Similar Datasets

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