Endothelial nitric oxide synthase (-786T>C) polymorphism and migraine susceptibility: A meta-analysis.

ABSTRACT: BACKGROUND:The aim of this study was to evaluate the correlation between endothelial nitric oxide synthase (eNOS) polymorphism (-786T>C) and migraine susceptibility in a meta-analysis. METHODS:A literature search was performed for case-control studies from inception to July 30, 2018 focusing on eNOS polymorphism (-786T>C) and risk of migraine. From 454 full-text articles, 6 were included in this study. Heterogeneity was assessed with the I index and quality assessment was performed using the Newcastle-Ottawa scale. RESULTS:CC genotype was not related to higher susceptibility of migraine compared with TT+ TC genotypes with significant difference (fixed effects model; OR?=?1.27; 95% CI?=?0.90-1.80; P?=?.17; I?=?18%). However, subgroup analysis showed CC variant increase the risk for migraine compared with TT+ TC genotypes in Caucasian populations (fixed effects model; OR?=?1.62; 95% CI?=?1.03-2.56; P?=?.04; I?=?18%), which could not be observed in non-Caucasian populations (fixed effects model; OR?=?0.88; 95% CI?=?0.51-1.53; P?=?.66; I?=?0%). There was no significant difference for other genotypes and alleles between patients with migraine and healthy controls (all P?>?.05). CONCLUSION:This meta-analysis indicated that CC variant increases the risk for migraine compared with TT + TC genotypes in Caucasian populations.

SUBMITTER: Dong H 

PROVIDER: S-EPMC6133471 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature