Ontology highlight
ABSTRACT:
SUBMITTER: Mucci A
PROVIDER: S-EPMC6135208 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Mucci Adele A Lopez-Rodriguez Elena E Hetzel Miriam M Liu Serena S Suzuki Takuji T Happle Christine C Ackermann Mania M Kempf Henning H Hillje Roman R Kunkiel Jessica J Janosz Ewa E Brennig Sebastian S Glage Silke S Bankstahl Jens P JP Dettmer Sabine S Rodt Thomas T Gohring Gudrun G Trapnell Bruce B Hansen Gesine G Trapnell Cole C Knudsen Lars L Lachmann Nico N Moritz Thomas T
Stem cell reports 20180809 3
Induced pluripotent stem cell (iPSC)-derived hematopoietic cells represent a highly attractive source for cell and gene therapy. Given the longevity, plasticity, and self-renewal potential of distinct macrophage subpopulations, iPSC-derived macrophages (iPSC-Mφ) appear of particular interest in this context. We here evaluated the airway residence, plasticity, and therapeutic efficacy of iPSC-Mφ in a murine model of hereditary pulmonary alveolar proteinosis (herPAP). We demonstrate that single pu ...[more]