Ontology highlight
ABSTRACT:
SUBMITTER: Cao L
PROVIDER: S-EPMC6135743 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Nature communications 20180912 1
As the sole target of broadly neutralizing antibodies (bnAbs) to HIV, the envelope glycoprotein (Env) trimer is the focus of vaccination strategies designed to elicit protective bnAbs in humans. Because HIV Env is densely glycosylated with 75-90 N-glycans per trimer, most bnAbs use or accommodate them in their binding epitope, making the glycosylation of recombinant Env a key aspect of HIV vaccine design. Upon analysis of three HIV strains, we here find that site-specific glycosylation of Env fr ...[more]