Ontology highlight
ABSTRACT:
SUBMITTER: Tiede S
PROVIDER: S-EPMC6148276 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Oncogenesis 20180920 9
Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase that regulates a plethora of downstream signaling pathways essential for cell migration, proliferation and death, processes that are exploited by cancer cells during malignant progression. These well-established tumorigenic activities, together with its high expression and activity in different cancer types, highlight FAK as an attractive target for cancer therapy. We have assessed and characterized the therapeutic potential and the bi ...[more]