Ontology highlight
ABSTRACT:
SUBMITTER: Zhang YL
PROVIDER: S-EPMC6138440 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Zhang Yin-Li YL Zhao Long-Wen LW Zhang Jue J Le Rongrong R Ji Shu-Yan SY Chen Chuan C Gao Yawei Y Li Dali D Gao Shaorong S Fan Heng-Yu HY
The EMBO journal 20180814 18
Mammalian oocytes and zygotes have the unique ability to reprogram a somatic cell nucleus into a totipotent state. SUV39H1/2-mediated histone H3 lysine-9 trimethylation (H3K9me3) is a major barrier to efficient reprogramming. How SUV39H1/2 activities are regulated in early embryos and during generation of induced pluripotent stem cells (iPSCs) remains unclear. Since expression of the CRL4 E3 ubiquitin ligase in oocytes is crucial for female fertility, we analyzed putative CRL4 adaptors (DCAFs) a ...[more]