Association of MTHFR and TNF-? genes polymorphisms with susceptibility to Legg-Calve-Perthes disease in Iranian children: A case-control study.
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ABSTRACT:
SUBMITTER: Azarpira MR
PROVIDER: S-EPMC6138855 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
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Association of MTHFR and TNF-α genes polymorphisms with susceptibility to Legg-Calve-Perthes disease in Iranian children: A case-control study.
Azarpira Mohammad Reza MR Ghilian Mohammad Mahdi MM Sobhan Mohammad Reza MR Mehdinezhad-Yazdi Masoud M Aghili Kazem K Miresmaeili Seyed Mohsen SM Neamatzadeh Hossein H
Journal of orthopaedics 20180907 4
<h4>Objective</h4>The aim of this study was to assess the association of MTHFR and TNF-α genes polymorphisms with Legg-Calvé-Perthes' disease (LCPD) risk in the Iranian children.<h4>Methods</h4>A total of 45 children with LCPD and 55 healthy controls were recruited to the study. Genotyping was performed via the RFLP-PCR method and genetic risk was calculated by odds ratio (OR) with its corresponding 95% confidence interval (CI).<h4>Results & conclusion</h4>Our case-control study failed to determ ...[more]
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