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Association of eNOS 27-bp VNTR, 894G>T and 786T>C polymorphisms with susceptibility to Legg-Calve-Perthes Disease in Iranian children.


ABSTRACT: Background:The aim of this study was to analyze the association of eNOS polymorphisms with risk of Legg-Calve-Perthes Disease (LCPD). Methods:The study comprised of 45 LCPD patients and 55 controls. The eNOS polymorphisms were genotyped with PCR and by PCR-RFLP. Results:The eNOS 894G?>?T and -786T?>?C polymorphisms were significantly associated with an increased risk of LCPD. However, there was no significant association between eNOS 27-bp VNTR polymorphism and LCPD risk. Conclusion:Our results suggest that the eNOS 894G?>?T and -786T?>?C polymorphisms may be a risk factor for LCPD in Iranian children, but not 27-bp VNTR polymorphism.

SUBMITTER: Azarpira MR 

PROVIDER: S-EPMC6403418 | biostudies-literature | 2019 Mar-Apr

REPOSITORIES: biostudies-literature

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Association of eNOS 27-bp VNTR, 894G>T and 786T>C polymorphisms with susceptibility to Legg-Calve-Perthes Disease in Iranian children.

Azarpira Mohammad Reza MR   Ghilian Mohammad Mahdi MM   Sobhan Mohammad Reza MR   Mahdinezhad-Yazdi Masoud M   Aghili Kazem K   Ahrar Hossein H   Neamatzadeh Hossein H  

Journal of orthopaedics 20190226 2


<h4>Background</h4>The aim of this study was to analyze the association of eNOS polymorphisms with risk of Legg-Calve-Perthes Disease (LCPD).<h4>Methods</h4>The study comprised of 45 LCPD patients and 55 controls. The eNOS polymorphisms were genotyped with PCR and by PCR-RFLP.<h4>Results</h4>The eNOS 894G > T and -786T > C polymorphisms were significantly associated with an increased risk of LCPD. However, there was no significant association between eNOS 27-bp VNTR polymorphism and LCPD risk.<h  ...[more]

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