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Synthesis and Characterization of trans-Dichlorotetrakis(imidazole)cobalt(III) Chloride: A New Cobalt(III) Coordination Complex with Potential Prodrug Properties.

ABSTRACT: Numerous therapies for the treatment of cancer have been explored with increasing evidence that the use of metal-containing compounds could prove advantageous as anticancer therapeutics. Previous works on Ru(III) complexes suggest that structurally similar Co(III) complexes may provide good alternative, low-cost, effective prodrugs. Herein, a new complex, trans-[Co(imidazole)4Cl2]Cl (2), has been synthesized in high yields utilizing ligand exchange under refluxing conditions. The structure of 2 has been characterized by elemental analysis, 1H and 13C·NMR, ESI-MS, CV, and UV-Vis. The ability of 2 to become reduced in the presence of ascorbic acid was probed demonstrating the likely reduction of the Co(III) metal center to Co(II). In addition, preliminary cell line testing on 2 shows a lack of cytotoxicity.

SUBMITTER: Hart KF 

PROVIDER: S-EPMC6140278 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Synthesis and Characterization of <i>trans</i>-Dichlorotetrakis(imidazole)cobalt(III) Chloride: A New Cobalt(III) Coordination Complex with Potential Prodrug Properties.

Hart Kaila F KF   Joe Natalie S NS   Miller Rebecca M RM   Nash Hannah P HP   Blake David J DJ   Morris Aimee M AM  

Bioinorganic chemistry and applications 20180903

Numerous therapies for the treatment of cancer have been explored with increasing evidence that the use of metal-containing compounds could prove advantageous as anticancer therapeutics. Previous works on Ru(III) complexes suggest that structurally similar Co(III) complexes may provide good alternative, low-cost, effective prodrugs. Herein, a new complex, <i>trans</i>-[Co(imidazole)<sub>4</sub>Cl<sub>2</sub>]Cl (<b>2</b>), has been synthesized in high yields utilizing ligand exchange under reflu  ...[more]

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