RNA Interference as a Prospective Tool for the Control of Human Viral Infections.
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ABSTRACT:
SUBMITTER: Levanova A
PROVIDER: S-EPMC6141738 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
RNA Interference as a Prospective Tool for the Control of Human Viral Infections.
Levanova Alesia A Poranen Minna M MM
Frontiers in microbiology 20180911
RNA interference (RNAi), which is mediated by small interfering RNAs (siRNAs) derived from viral genome or its replicative intermediates, is a natural antiviral defense in plants, fungi, and invertebrates. Whether RNAi naturally protects humans from viral invasion is still a matter of debate. Nevertheless, exogenous siRNAs are able to halt viral infection in mammals. The current review critically evaluates the production of antiviral siRNAs, delivery techniques to the infection sites, as well as ...[more]
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