Transient HES5 Activity Instructs Mesodermal Cells toward a Cardiac Fate.
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ABSTRACT:
SUBMITTER: Freire AG
PROVIDER: S-EPMC5511108 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Publications
Transient HES5 Activity Instructs Mesodermal Cells toward a Cardiac Fate.
Freire Ana G AG Waghray Avinash A Soares-da-Silva Francisca F Resende Tatiana P TP Lee Dung-Fang DF Pereira Carlos-Filipe CF Nascimento Diana S DS Lemischka Ihor R IR Pinto-do-Ó Perpétua P
Stem cell reports 20170622 1
Notch signaling plays a role in specifying a cardiac fate but the downstream effectors remain unknown. In this study we implicate the Notch downstream effector HES5 in cardiogenesis. We show transient Hes5 expression in early mesoderm of gastrulating embryos and demonstrate, by loss and gain-of-function experiments in mouse embryonic stem cells, that HES5 favors cardiac over primitive erythroid fate. Hes5 overexpression promotes upregulation of the cardiac gene Isl1, while the hematopoietic regu ...[more]
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