Ontology highlight
ABSTRACT:
SUBMITTER: Long W
PROVIDER: S-EPMC2824333 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Long Weiwen W Yi Ping P Amazit Larbi L LaMarca Heather L HL Ashcroft Felicity F Kumar Rakesh R Mancini Michael A MA Tsai Sophia Y SY Tsai Ming-Jer MJ O'Malley Bert W BW
Molecular cell 20100201 3
EGF induces signal transduction between EGFR and FAK, and FAK is required for EGF-induced cell migration. It is unknown, however, what factor mediates the interaction between EGFR and FAK and leads to EGF-induced FAK phosphorylation. Here, we identify SRC-3Delta4, a splicing isoform of the SRC-3 oncogene, as a signaling adaptor that links EGFR and FAK and promotes EGF-induced phosphorylations of FAK and c-Src. We identify three PAK1-mediated phosphorylations in SRC-3Delta4 that promote the local ...[more]