Ontology highlight
ABSTRACT:
SUBMITTER: Lubkowski J
PROVIDER: S-EPMC6143405 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Lubkowski Jacek J Sonmez Cem C Smirnov Sergey V SV Anishkin Andriy A Kotenko Sergei V SV Wlodawer Alexander A
Journal of immunology (Baltimore, Md. : 1950) 20180815 7
Crystal structure of the ternary complex of human IL-24 with two receptors, IL-22R1 and IL-20R2, has been determined at 2.15 Å resolution. A crystallizable complex was created by a novel approach involving fusing the ligand with a flexible linker to the presumed low-affinity receptor, and coexpression of this construct in <i>Drosophila</i> S2 cells together with the presumed high-affinity receptor. This approach, which may be generally applicable to other multiprotein complexes with low-affinity ...[more]