I-Motif DNA: structural features and significance to cell biology.
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ABSTRACT:
SUBMITTER: Abou Assi H
PROVIDER: S-EPMC6144788 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Publications
i-Motif DNA: structural features and significance to cell biology.
Abou Assi Hala H Garavís Miguel M González Carlos C Damha Masad J MJ
Nucleic acids research 20180901 16
The i-motif represents a paradigmatic example of the wide structural versatility of nucleic acids. In remarkable contrast to duplex DNA, i-motifs are four-stranded DNA structures held together by hemi- protonated and intercalated cytosine base pairs (C:C+). First observed 25 years ago, and considered by many as a mere structural oddity, interest in and discussion on the biological role of i-motifs have grown dramatically in recent years. In this review we focus on structural aspects of i-motif f ...[more]
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