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I-Motif DNA: structural features and significance to cell biology.


ABSTRACT: The i-motif represents a paradigmatic example of the wide structural versatility of nucleic acids. In remarkable contrast to duplex DNA, i-motifs are four-stranded DNA structures held together by hemi- protonated and intercalated cytosine base pairs (C:C+). First observed 25 years ago, and considered by many as a mere structural oddity, interest in and discussion on the biological role of i-motifs have grown dramatically in recent years. In this review we focus on structural aspects of i-motif formation, the factors leading to its stabilization and recent studies describing the possible role of i-motifs in fundamental biological processes.

SUBMITTER: Abou Assi H 

PROVIDER: S-EPMC6144788 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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i-Motif DNA: structural features and significance to cell biology.

Abou Assi Hala H   Garavís Miguel M   González Carlos C   Damha Masad J MJ  

Nucleic acids research 20180901 16


The i-motif represents a paradigmatic example of the wide structural versatility of nucleic acids. In remarkable contrast to duplex DNA, i-motifs are four-stranded DNA structures held together by hemi- protonated and intercalated cytosine base pairs (C:C+). First observed 25 years ago, and considered by many as a mere structural oddity, interest in and discussion on the biological role of i-motifs have grown dramatically in recent years. In this review we focus on structural aspects of i-motif f  ...[more]

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