Lung colonization by Aspergillus fumigatus is controlled by ZNF77.
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ABSTRACT:
SUBMITTER: Gago S
PROVIDER: S-EPMC6147781 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Publications
Lung colonization by Aspergillus fumigatus is controlled by ZNF77.
Gago Sara S Overton Nicola L D NLD Ben-Ghazzi Nagwa N Novak-Frazer Lilyann L Read Nick D ND Denning David W DW Bowyer Paul P
Nature communications 20180920 1
Aspergillus fumigatus is a critical pathogen of humans. Exposure to A. fumigatus conidia occurs frequently but is normally cleared from the respiratory airways. In contrast, individuals with respiratory diseases are often highly colonized by fungi. Here, we use genome-edited epithelial cells to show that the genetic variant rs35699176 in ZNF77 causes loss of integrity of the bronchial epithelium and increases levels of extracellular matrix proteins. These changes promote A. fumigatus conidial ad ...[more]
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