Ontology highlight
ABSTRACT:
SUBMITTER: Ibrahim AM
PROVIDER: S-EPMC6148073 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Ibrahim Ayman M AM Sabet Salwa S El-Ghor Akmal A AA Kamel Nora N Anis Shady E SE Morris Joanna S JS Stein Torsten T
Scientific reports 20180920 1
Fibulin-2 (FBLN2) is a secreted extracellular matrix glycoprotein which has been associated with tissue development and remodelling. In the mouse mammary gland, FBLN2 can be detected during ductal morphogenesis in cap cells and myoepithelial cells at puberty and early pregnancy, respectively. In an attempt to assign its function, we knocked down Fbln2 in the mouse mammary epithelial cell line EpH4. FBLN2 reduction led to an increase in the size of spheroidal structures when compared to scrambled ...[more]