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Cytotoxic Compounds from Aloe megalacantha.

ABSTRACT: Phytochemical investigation of the ethyl acetate extract of the roots of Aloe megalacantha led to the isolation of four new natural products-1,8-dimethoxynepodinol (1), aloesaponarin III (2), 10-O-methylchrysalodin (3) and methyl-26-O-feruloyl-oxyhexacosanate (4)-along with ten known compounds. All purified metabolites were characterized by NMR, mass spectrometric analyses and comparison with literature data. The isolates were evaluated for their cytotoxic activity against a human cervix carcinoma cell line KB-3-1 and some of them exhibited good activity, with aloesaponarin II (IC₅₀ = 0.98 µM) being the most active compound.

SUBMITTER: Abdissa N

PROVIDER: S-EPMC6152336 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Cytotoxic Compounds from Aloe megalacantha.

Abdissa Negera N Gohlke Sebastian S Frese Marcel M Sewald Norbert N

Molecules (Basel, Switzerland) 20170707 7

Phytochemical investigation of the ethyl acetate extract of the roots of Aloe megalacantha led to the isolation of four new natural products-1,8-dimethoxynepodinol (1), aloesaponarin III (2), 10-O-methylchrysalodin (3) and methyl-26-O-feruloyl-oxyhexacosanate (4)-along with ten known compounds. All purified metabolites were characterized by NMR, mass spectrometric analyses and comparison with literature data. The isolates were evaluated for their ...[more]

PMID: 28686200

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