Ontology highlight
ABSTRACT:
SUBMITTER: Gu T
PROVIDER: S-EPMC6152701 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20170621 6
Scutellarin (<b>1</b>) has been widely used to treat acute cerebral infarction in clinic, but poor aqueous solubility decreases its bioavailability. Interestingly, scutellarin (<b>1</b>) could be metabolized into scutellarein (<b>2</b>) in vivo. In this study, a sulfonic group was introduced at position C-8 of scutellarein (<b>2</b>) to enhance the aqueous solubility of the obtained derivative (<b>3</b>). DPPH (1,1-diphenyl-2-picrylhydrazyl)-radical scavenging ability and antithrombic activity w ...[more]