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Spermatogenic and spermatotoxic effects of Telfairia occidentalis (Ugu) aqueous leaves extract in adult male Wistar rats (Rattus novergicus).


ABSTRACT: Telfairia occidentalis (TO), commonly called Pumpkin is a plant with numerous medicinal values. Here we investigated the effects of Telfairia occidentalis aqueous leaves extract on the testis of Adult Male Wistar Rats (Rattus novergicus). Thirty-Five (35) adult male rats were grouped into seven (7) containing five (n?=?5) rats in each group. Group A served as control, group B and C received 100?mg/kg body weight of Telfairia occidentalis for two and four weeks respectively, group D and E received 200?mg/kg body weight of Telfairia occidentalis for two and four weeks respectively, while group F and G received 300?mg/kg body weight of Telfairia occidentalis for two and four weeks respectively. Serum testosterone levels, testicular histomorphometry, Semen and histological analysis were observed. A dose dependent significant (P?T. occidentalis leaf extract over a period of time had spermatogenic and testiculoprotective properties while at high doses, its spermatotoxic properties were observed.

SUBMITTER: Yawson Emmanuel O 

PROVIDER: S-EPMC6154512 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Spermatogenic and spermatotoxic effects of <i>Telfairia occidentalis</i> (Ugu) aqueous leaves extract in adult male Wistar rats (<i>Rattus novergicus</i>).

Yawson Emmanuel O O   Obasi Kosisochukwu Kingsley KK   Lawal Ismail I  

Toxicology reports 20180817


<i>Telfairia occidentalis</i> (TO), commonly called Pumpkin is a plant with numerous medicinal values. Here we investigated the effects of <i>Telfairia occidentalis</i> aqueous leaves extract on the testis of Adult Male Wistar Rats <i>(Rattus novergicus).</i> Thirty-Five (35) adult male rats were grouped into seven (7) containing five (n = 5) rats in each group. Group A served as control, group B and C received 100 mg/kg body weight of <i>Telfairia occidentalis</i> for two and four weeks respect  ...[more]

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