Dataset Information

Spermatogenic and spermatotoxic effects of Telfairia occidentalis (Ugu) aqueous leaves extract in adult male Wistar rats (Rattus novergicus).

ABSTRACT: Telfairia occidentalis (TO), commonly called Pumpkin is a plant with numerous medicinal values. Here we investigated the effects of Telfairia occidentalis aqueous leaves extract on the testis of Adult Male Wistar Rats (Rattus novergicus). Thirty-Five (35) adult male rats were grouped into seven (7) containing five (n?=?5) rats in each group. Group A served as control, group B and C received 100?mg/kg body weight of Telfairia occidentalis for two and four weeks respectively, group D and E received 200?mg/kg body weight of Telfairia occidentalis for two and four weeks respectively, while group F and G received 300?mg/kg body weight of Telfairia occidentalis for two and four weeks respectively. Serum testosterone levels, testicular histomorphometry, Semen and histological analysis were observed. A dose dependent significant (P?T. occidentalis leaf extract over a period of time had spermatogenic and testiculoprotective properties while at high doses, its spermatotoxic properties were observed.

SUBMITTER: Yawson Emmanuel O

PROVIDER: S-EPMC6154512 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Spermatogenic and spermatotoxic effects of Telfairia occidentalis (Ugu) aqueous leaves extract in adult male Wistar rats (Rattus novergicus).

Yawson Emmanuel O O Obasi Kosisochukwu Kingsley KK Lawal Ismail I

Toxicology reports 20180817

Telfairia occidentalis (TO), commonly called Pumpkin is a plant with numerous medicinal values. Here we investigated the effects of Telfairia occidentalis aqueous leaves extract on the testis of Adult Male Wistar Rats (Rattus novergicus). Thirty-Five (35) adult male rats were grouped into seven (7) containing five (n = 5) rats in each group. Group A served as control, group B and C received 100 mg/kg body weight of Telfairia occidentalis for two and four weeks respect ...[more]

PMID: 30258790

Similar Datasets

Project description:BACKGROUND:Combretum molle R.B/G. Don (Combretaceae) is a graceful deciduous shrub, distributed especially in tropical Africa and used in traditional medicine in the treatment of malaria, diabetes, and bacterial, liver and cardiovascular deseases. To our knowledge, no long-term toxicity studies of C. molle has ever been realized yet. METHODS:The long-term toxicity study was conducted in accordance with OECD 408 guidelines with slight modifications. In fact, rats were divided in groups and treated orally with CMAE at doses of 62.5, 125 and 250?mg/kg for 6?months. The general behavior and signs of toxicity of the rats were daily observed. Body weight, food and water intake were recorded every 2?months for 6?months. At the end of treatment period, urine and blood samples were collected for hematological, biochemical and antioxidant estimations. Immediately, internal organs were collected and weighed. RESULTS:The results showed that no mortality and visible signs of the toxicity were recorded in all experimental animals. The administration of CMAE had no significant effects on body weight, organ weights, serum electrolyte, and food and water intake. However, all doses of CMAE produced an increase in high density lipoprotein cholesterol, white blood cells, platelets, glutathione, and a decrease in low density lipoprotein cholesterol and malondialdehyde rate. CMAE at doses of 125 and 250?mg/kg decreased in serum proteins and the activity of aspartate amino transferase, and increased the activity of catalase. In addition, CMAE (250?mg/kg) significantly decreased the alanine aminotransferase activity and the level of triglycerides, very low density cholesterol, total proteins and creatinine, and increased in renal clearance, red blood cells, hemoglobin, hematocrit and superoxide dismutase activity. CONCLUSIONS:At the end of this study, no signs of major intoxication was noted during 6?months of treatment. These results suggest that long-term consumption of CMAE at the therapeutic dose (250?mg/kg) presents low risks to human health.

Project description:BackgroundArecae semen (AS) is officially recorded in Chinese Pharmacopoeia and it is known for its multiple functions, including antidepressive, antioxidant, anti-inflammatory, and cholesterol-lowering effects, which have been confirmed by modern pharmacological study. Previous study in our laboratory showed that long-term oral administration of Arecae semen (AS) is officially recorded in Chinese Pharmacopoeia and it is known for its multiple functions, including antidepressive, antioxidant, anti-inflammatory, and cholesterol-lowering effects, which have been confirmed by modern pharmacological study. Previous study in our laboratory showed that long-term oral administration of Hypothesis. The aim of this work was to characterize the metabolome, evaluate the metabolic changes, and study the mechanisms of the toxicity induced by different treatment doses of ASAE via metabolomics.MethodsWistar rats were administered orally two different doses of ASAE (1500 and 4500 mg/kg/d) for 30 days. The investigation was carried out to evaluate the safety of ASAE. And, the UPLC-HDMS-based serum metabolomics in conjunction with multivariate statistical techniques was applied to investigate the serum metabolite profile and potential markers of toxicity induced by different doses of ASAE.ResultsCoupled with blood biochemistry and histopathology results, the significant difference in metabolic profiling was observed between 1500 and 4500 mg/kg/d dosages of ASAE-treated rats and normal rats by using pattern recognition analysis, indicating that changes in serum metabolites must have occurred. Some significant changed metabolites such as arachidonic acid, linoleic acid, stearic acid, and LPC (18 : 1) have been found and identified. These biochemical changes in serum metabolites are related to the perturbation of linoleic acid metabolism, arachidonic acid metabolism, glycerophospholipid metabolism, and purine metabolism, which may be helpful to further understand the cardiotoxicity and neurotoxicity of ASAE.ConclusionThe study shows that the metabolomic method may be a valuable tool for studying the essence of toxicity induced by traditional Chinese medicine.

Dataset Information

Spermatogenic and spermatotoxic effects of Telfairia occidentalis (Ugu) aqueous leaves extract in adult male Wistar rats (Rattus novergicus).

Publications

Spermatogenic and spermatotoxic effects of <i>Telfairia occidentalis</i> (Ugu) aqueous leaves extract in adult male Wistar rats (<i>Rattus novergicus</i>).

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets