Therapeutic Potential of Targeting the Th17/Treg Axis in Autoimmune Disorders.
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ABSTRACT:
SUBMITTER: Fasching P
PROVIDER: S-EPMC6155880 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
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Therapeutic Potential of Targeting the Th17/Treg Axis in Autoimmune Disorders.
Fasching Patrizia P Stradner Martin M Graninger Winfried W Dejaco Christian C Fessler Johannes J
Molecules (Basel, Switzerland) 20170114 1
A disruption of the crucial balance between regulatory T-cells (Tregs) and Th17-cells was recently implicated in various autoimmune disorders. Tregs are responsible for the maintenance of self-tolerance, thus inhibiting autoimmunity, whereas pro-inflammatory Th17-cells contribute to the induction and propagation of inflammation. Distortion of the Th17/Treg balance favoring the pro-inflammatory Th17 side is hence suspected to contribute to exacerbation of autoimmune disorders. This review aims t ...[more]
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