Ontology highlight
ABSTRACT:
SUBMITTER: Taraborrelli L
PROVIDER: S-EPMC6156229 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Taraborrelli Lucia L Peltzer Nieves N Montinaro Antonella A Kupka Sebastian S Rieser Eva E Hartwig Torsten T Sarr Aida A Darding Maurice M Draber Peter P Haas Tobias L TL Akarca Ayse A Marafioti Teresa T Pasparakis Manolis M Bertin John J Gough Peter J PJ Bouillet Philippe P Strasser Andreas A Leverkus Martin M Silke John J Walczak Henning H
Nature communications 20180925 1
The linear ubiquitin chain assembly complex (LUBAC), composed of HOIP, HOIL-1 and SHARPIN, is required for optimal TNF-mediated gene activation and to prevent cell death induced by TNF. Here, we demonstrate that keratinocyte-specific deletion of HOIP or HOIL-1 (E-KO) results in severe dermatitis causing postnatal lethality. We provide genetic and pharmacological evidence that the postnatal lethal dermatitis in Hoip<sup>E-KO</sup> and Hoil-1<sup>E-KO</sup> mice is caused by TNFR1-induced, caspase ...[more]