An adaptive gene-based test for methylation data.
Ontology highlight
ABSTRACT:
SUBMITTER: Wu C
PROVIDER: S-EPMC6157100 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
An adaptive gene-based test for methylation data.
Wu Chong C Park Jun Young JY Guan Weihua W Pan Wei W
BMC proceedings 20180917 Suppl 9
DNA methylation plays an important role in normal human development and disease. In epigenome-wide association studies (EWAS), a univariate test for association between a phenotype and each cytosine-phosphate-guanine (CpG) site has been widely used. Given the number of CpG sites tested in EWAS, a stringent significance cutoff is required to adjust for multiple testing; in addition, multiple nearby CpG sites may be associated with the phenotype, which is ignored by a univariate test. These two fa ...[more]
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