Ontology highlight
ABSTRACT:
SUBMITTER: Park JY
PROVIDER: S-EPMC6157189 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Park Jun Young JY Wu Chong C Pan Wei W
BMC genetics 20180917 Suppl 1
<h4>Background</h4>We propose a gene-level association test that accounts for individual relatedness and population structures in pedigree data in the framework of linear mixed models (LMMs). Our method data-adaptively combines the results across a class of score-based tests, only requiring fitting a single null model (under the null hypothesis) for the whole genome, thereby being computationally efficient.<h4>Results</h4>We applied our approach to test for association with the high-density lipo ...[more]