Ontology highlight
ABSTRACT:
SUBMITTER: Du J
PROVIDER: S-EPMC6158500 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Du Junqing J Kirk Brian B Zeng Jia J Ma Jianpeng J Wang Qinghua Q
Nucleic acids research 20180901 17
Polycomb group (PcG) and Trithorax group (TrxG) proteins are essential for maintaining epigenetic memory in both embryonic stem cells and differentiated cells. To date, how they are localized to hundreds of specific target genes within a vertebrate genome had remained elusive. Here, by focusing on short cis-acting DNA elements of single functions, we discovered three classes of response elements in human genome: Polycomb response elements (PREs), Trithorax response elements (TREs) and Polycomb/T ...[more]