Ontology highlight
ABSTRACT:
SUBMITTER: Liu H
PROVIDER: S-EPMC6159523 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Liu Hongfei H Lorenzini Paolo A PA Zhang Fan F Xu Shaohai S Wong Mei Su M MSM Zheng Jie J Roca Xavier X
Nucleic acids research 20180701 12
We report the detailed transcriptomic profiles of human innate myeloid cells using RNA sequencing. Monocytes migrate from blood into infected or wounded tissue to differentiate into macrophages, and control inflammation via phagocytosis or cytokine secretion. We differentiated culture primary monocytes with either GM- or M-CSF to obtain pro- or anti-inflammatory macrophages, and respectively activated them with either LPS/IFNγ or anti-inflammatory cytokines. We also treated the THP-1 monocytic c ...[more]