Somatic Trp53 mutations differentially drive breast cancer and evolution of metastases.
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ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC6160420 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Publications
Somatic Trp53 mutations differentially drive breast cancer and evolution of metastases.
Zhang Yun Y Xiong Shunbin S Liu Bin B Pant Vinod V Celii Francis F Chau Gilda G Elizondo-Fraire Ana C AC Yang Peirong P You Mingjian James MJ El-Naggar Adel K AK Navin Nicholas E NE Lozano Guillermina G
Nature communications 20180927 1
TP53 mutations are the most frequent genetic alterations in breast cancer and are associated with more aggressive disease and worse overall survival. We have created two conditional mutant Trp53 alleles in the mouse that allow expression of Trp53R172H or Trp53R245W missense mutations in single cells surrounded by a normal stroma and immune system. Mice with Trp53 mutations in a few breast epithelial cells develop breast cancers with high similarity to human breast cancer including triple negativ ...[more]
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