Ontology highlight
ABSTRACT:
SUBMITTER: Gambera S
PROVIDER: S-EPMC6162235 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Gambera Stefano S Abarrategi Ander A González-Camacho Fernando F Morales-Molina Álvaro Á Roma Josep J Alfranca Arantzazu A García-Castro Javier J
Nature communications 20180928 1
Osteosarcoma is a type of bone tumour characterized by considerable levels of phenotypic heterogeneity, aneuploidy, and a high mutational rate. The life expectancy of osteosarcoma patients has not changed during the last three decades and thus much remains to be learned about the disease biology. Here, we employ a RGB-based single-cell tracking system to study the clonal dynamics occurring in a de novo-induced murine osteosarcoma model. We show that osteosarcoma cells present initial polyclonal ...[more]