Long intergenic non-coding RNAs have an independent impact on survival in multiple myeloma.
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ABSTRACT:
SUBMITTER: Samur MK
PROVIDER: S-EPMC6163089 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Publications
Long intergenic non-coding RNAs have an independent impact on survival in multiple myeloma.
Samur Mehmet Kemal MK Minvielle Stephane S Gulla Annamaria A Fulciniti Mariateresa M Cleynen Alice A Aktas Samur Anil A Szalat Raphael R Shammas Masood M Magrangeas Florence F Tai Yu-Tzu YT Auclair Daniel D Keats Jonathan J Richardson Paul P Attal Michel M Moreau Philippe P Anderson Kenneth C KC Parmigiani Giovanni G Avet-Loiseau Hervé H Munshi Nikhil C NC
Leukemia 20180329 12
Although long intergenic non-coding RNAs (lincRNA) role in various cancers is described, their significance in Multiple Myeloma (MM) remains poorly defined. Here we have studied the lincRNA profile and their clinical impact in MM. We performed RNA-seq on MM cells from 308 newly diagnosed and uniformly treated patients, 16 normal plasma cells and utilized RNA-seq data from 532 newly diagnosed patients from CoMMpass study to analyze for lincRNAs. We observed 869 differentially expressed lincRNAs i ...[more]
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