Ontology highlight
ABSTRACT:
SUBMITTER: Fasci D
PROVIDER: S-EPMC6166682 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Molecular & cellular proteomics : MCP 20180718 10
Cells organize their actions partly through tightly controlled protein-protein interactions-collectively termed the interactome. Here we use crosslinking mass spectrometry (XL-MS) to chart the protein-protein interactions in intact human nuclei. Overall, we identified ∼8,700 crosslinks, of which 2/3 represent links connecting distinct proteins. From these data, we gain insights on interactions involving histone proteins. We observed that core histones on the nucleosomes expose well-defined inter ...[more]