Ontology highlight
ABSTRACT:
SUBMITTER: Nelson CA
PROVIDER: S-EPMC6166816 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Nelson Christopher A CA Wilen Craig B CB Dai Ya-Nan YN Orchard Robert C RC Kim Arthur S AS Stegeman Roderick A RA Hsieh Leon L LL Smith Thomas J TJ Virgin Herbert W HW Fremont Daved H DH
Proceedings of the National Academy of Sciences of the United States of America 20180907 39
Murine norovirus (MNoV) is closely related to human norovirus (HNoV), an infectious agent responsible for acute gastroenteritis worldwide. Here we report the X-ray crystal structure of the dimeric MNoV VP1 protruding (P) domain in complex with its cellular receptor CD300lf. CD300lf binds the P domain with a 2:2 stoichiometry, engaging a cleft between the AB and DE loops of the P2 subdomain at a site that overlaps the epitopes of neutralizing antibodies. We also identify that bile acids are cofac ...[more]