Ontology highlight
ABSTRACT:
SUBMITTER: Holtgrewe M
PROVIDER: S-EPMC6168503 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Scientific reports 20181002 1
A genome-wide evaluation of the effects of ionizing radiation on mutation induction in the mouse germline has identified multisite de novo mutations (MSDNs) as marker for previous exposure. Here we present the results of a small pilot study of whole genome sequencing in offspring of soldiers who served in radar units on weapon systems that were emitting high-frequency radiation. We found cases of exceptionally high MSDN rates as well as an increased mean in our cohort: While a MSDN mutation is d ...[more]